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carboxypeptidase B2 (carboxypeptidase U, CPU, thrombin-activable fibrinolysis inhibitor, TAFI, plasma carboxypeptidase B, pCPB, CPB2)
Function:
- cleaves C-terminal Arg or Lys from biologically active peptides including kinins or anaphylatoxins in the circulation thus regulating their activities
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the peptidase M14 family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression: plasma; synthesized in the liver
General
carboxypeptidase B
glycoprotein
Properties
SIZE: entity length = 423 aa
MW = 48 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N44}
N-glycosylation site {N73}
N-glycosylation site {N85}
N-glycosylation site {N108}
cysteine residue {C178}
MODIFICATION: cysteine residue {C191}
Zn+2-binding site
SITE: 181-181
Zn+2-binding site
SITE: 184-184
cysteine residue {C191}
MODIFICATION: cysteine residue {C178}
N-glycosylation site {N241}
cysteine residue {C250}
MODIFICATION: cysteine residue {C274}
cysteine residue {C265}
MODIFICATION: cysteine residue {C279}
cysteine residue {C274}
MODIFICATION: cysteine residue {C250}
cysteine residue {C279}
MODIFICATION: cysteine residue {C265}
Zn+2-binding site
SITE: 310-310
glutamate residue {E385}
Database Correlations
OMIM 603101
UniProt Q96IY4
PFAM correlations
Entrez Gene 1361
KEGG correlations
ENZYME 3.4.17.20
References
UniProt :accession Q96IY4