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carboxypeptidase-B1 (pancreas-specific protein, PASP, CPB1, CPB, PCPB)
Function:
- preferential release of a C-terminal lysine or arginine amino acid
Cofactor: binds 1 Zn+2 per subunit
Structure: belongs to the peptidase M14 family
Compartment: secreted
Expression: pancreas
General
carboxypeptidase B
Properties
SIZE: entity length = 417 aa
MW = 47 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
cysteine residue {C173}
MODIFICATION: cysteine residue {C186}
Zn+2-binding site
SITE: 176-176
Zn+2-binding site
SITE: 179-179
cysteine residue {C186}
MODIFICATION: cysteine residue {C173}
cysteine residue {C245}
MODIFICATION: cysteine residue {C268}
cysteine residue {C259}
MODIFICATION: cysteine residue {C273}
cysteine residue {C268}
MODIFICATION: cysteine residue {C245}
cysteine residue {C273}
MODIFICATION: cysteine residue {C259}
Zn+2-binding site
SITE: 304-304
glutamate residue {E378}
Database Correlations
OMIM 114852
UniProt P15086
Entrez Gene 1360
ENZYME 3.4.17.2
References
UniProt :accession P15086