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carboxypeptidase A6 (CPA6, CPAH)
Function:
- release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the peptidase M14 family
Compartment: secreted (putative)
Alternative splicing: named isoforms=3
Pathology:
- chromosomal translocation t(6;8)(q26;q13) disrupting CPA6 was found in a patient with Duane retraction syndrome
General
carboxypeptidase-A
glycoprotein
Properties
SIZE: entity length = 437 aa
MW = 51 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-30}
N-glycosylation site {N89}
N-glycosylation site {N153}
Substrate binding {196-199}
MOTIF: Zn+2-binding site
SITE: 196-196
Zn+2-binding site
SITE: 199-199
binding site
SITE: 254-254
FOR-BINDING-OF: Substrate
cysteine residue {C265}
MODIFICATION: cysteine residue {C288}
Substrate binding {271-272}
cysteine residue {C288}
MODIFICATION: cysteine residue {C265}
Zn+2-binding site
SITE: 324-324
Substrate binding {325-326}
glutamate residue {E398}
N-glycosylation site {N427}
Database Correlations
OMIM 126800
UniProt Q8N4T0
PFAM correlations
Entrez Gene 57094
Kegg hsa:5709
ENZYME 3.4.17.1
References
UniProt :accession Q8N4T0