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carboxypeptidase A5 (CPA5)
Function:
- release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the peptidase M14 family
Compartment: secreted (putative)
Alternative splicing: named isoforms=2
Expression: Expression is very low or not detectable
General
carboxypeptidase-A
Properties
SIZE: entity length = 436 aa
MW = 49 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-33}
Substrate binding {196-199}
MOTIF: Zn+2-binding site
SITE: 196-196
Zn+2-binding site
SITE: 199-199
binding site
SITE: 254-254
FOR-BINDING-OF: Substrate
cysteine residue {C265}
MODIFICATION: cysteine residue {C288}
Substrate binding {271-272}
cysteine residue {C288}
MODIFICATION: cysteine residue {C265}
Zn+2-binding site
SITE: 323-323
Substrate binding {324-325}
glutamate residue {E397}
Database Correlations
UniProt Q8WXQ8
PFAM correlations
Entrez Gene 93979
Kegg hsa:9397
ENZYME 3.4.17.1
References
UniProt :accession Q8WXQ8