Search
carboxypeptidase A4 (CPA4, UNQ694/PRO1339)
Function:
- metalloprotease
- may be involved in histone hyperacetylation pathway
- interacts with LXN
Cofactor: binds 1 Zn+2 per subunit
Structure: belongs to the peptidase M14 family
Compartment: secreted (putative)
Expression:
- fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver & lung
- except for fetal brain that shows no imprinting, expression found preferentially from maternal allele
- up-regulated by inhibitors of histone dacetylation
General
carboxypeptidase-A
glycoprotein
Properties
SIZE: entity length = 421 aa
MW = 47 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
Substrate binding {181-184}
MOTIF: Zn+2-binding site
SITE: 181-181
Zn+2-binding site
SITE: 184-184
binding site
SITE: 239-239
FOR-BINDING-OF: Substrate
cysteine residue {C250}
MODIFICATION: cysteine residue {C273}
Substrate binding {256-257}
N-glycosylation site {N260}
cysteine residue {C273}
MODIFICATION: cysteine residue {C250}
Zn+2-binding site
SITE: 308-308
Substrate binding {309-310}
glutamate residue {E382}
Database Correlations
OMIM 607635
UniProt Q9UI42
PFAM correlations
Entrez Gene 51200
References
UniProt :accession Q9UI42