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carboxypeptidase-A3 (mast cell carboxypeptidase-A, CPA3)
Function:
- release of a C-terminal amino acid
- little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the peptidase M14 family
Compartment: secretory granules
General
carboxypeptidase-A
Properties
SIZE: entity length = 417 aa
MW = 49 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
cysteine residue {C173}
MODIFICATION: cysteine residue {C186}
Zn+2-binding site
SITE: 176-176
Zn+2-binding site
SITE: 179-179
cysteine residue {C186}
MODIFICATION: cysteine residue {C173}
cysteine residue {C245}
MODIFICATION: cysteine residue {C268}
cysteine residue {C268}
MODIFICATION: cysteine residue {C245}
Zn+2-binding site
SITE: 304-304
glutamate residue {E378}
Database Correlations
OMIM 114851
UniProt P15088
PFAM correlations
Entrez Gene 1359
ENZYME 3.4.17.1
References
UniProt :accession P15088