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carboxylesterase 7; cauxin; carboxylesterase-like urinary excreted protein homolog (CES7, CES5A)

Function: - role in the detoxification of xenobiotics & in the activation of ester & amide prodrugs (putative) carboxylic ester + H2O alcohol + carboxylate Structure: - belongs to the type-B carboxylesterase/lipase family - N-glycosylated (putative) Compartment: secreted (putative) Alternative splicing: named isoforms=3 Note: was named CES5

General

carboxylase (carboxylic ester hydrolase) glycoprotein secreted protein

Properties

SIZE: entity length = 575 aa MW = 64 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} cysteine residue {C94} MODIFICATION: cysteine residue {C121} cysteine residue {C121} MODIFICATION: cysteine residue {C94} serine residue {S226} N-glycosylation site {N281} active site glutamate residue {E345} N-glycosylation site {N363} histidine residue {H454} N-glycosylation site {N513} N-glycosylation site {N524}

Database Correlations

UniProt Q6NT32 Pfam PF00135 ENZYME 3.1.1.1

References

UniProt :accession Q6NT32