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carboprost; 15-methyl-prostaglandin F2-alpha (Hemabate)

Tradename: Hemabate. (carboprost tromethamine) Indications: 1) post-partum bleeding 2) termination of pregnancy Dosage: - 250 ug IM or directly into the uterus every 15-20 min up to 4 doses. Injection: carboprost 25 ug, tromethamine 83 ug/mL (1 mL) Adverse effects: 1) common (> 10%) - nausea 2) less common (1-10%) - flushing 3) uncommon (< 1%) - hypertension, hypotension, hiccups, drowsiness, vertigo, breast tenderness, nervousness, fever, headache, dry mouth, vomiting, diarrhea, vasovagal syndrome, hematemesis, muscle pain, dystonia, blurred vision, bladder spasms, cough, asthma, respiratory distress, taste disturbance, septic shock

General

endocrine agent prostaglandin analog; prostanoid

Properties

MISC-INFO: elimination route LIVER KIDNEY

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998