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carbonic anhydrase-2 (carbonic anhydrase-B, CA2)
Function:
- reversible hydration of carbon dioxide interacts with SLC4A4
- interaction with SLC4A7 regulates SLC4A7 transporter activity
- role in osteoclast function & bone resorption
H3CO3 CO2 + H2O
Cofactor: Zn+2
Structure: belongs to the alpha-carbonic anhydrase family
Compartment: cytoplasm
Expression:
- only carbonic anhydrase isozyme expressed in kidney
- also expressed in brain & erythrocytes
Pathology:
- defects in CA2 are the cause of carbonic anhydrase 2 deficiency
Laboratory:
- carbonic anhydrase 2 Ab in serum
General
carbonic anhydrase (dehydratase)
membrane protein
Properties
SIZE: entity length = 260 aa
MW = 29 kD
COMPARTMENT: cytoplasm
MOTIF: histidine residue {H64}
asparagine residue {N67}
Zn+2-binding site
SITE: 94-94
Zn+2-binding site
SITE: 96-96
Zn+2-binding site
SITE: 119-119
tyrosine residue {Y127}
Database Correlations
OMIM 259730
UniProt P00918
Pfam PF00194
Entrez Gene 760
Kegg hsa:760
ENZYME 4.2.1.1
References
- OMIM :accession 259730
- UniProt :accession P00918
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CA2