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carbonic anhydrase-14 (carbonic dehydratase 14, CA14)
Function:
- reversible hydration of carbon dioxide
H2CO3 CO2 + H2O
Cofactor: Zn+2 (putative)
Structure: belongs to the alpha-carbonic anhydrase family
Compartment: membrane
Expression:
- high expression in all parts of the central nervous system
- lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder & skeletal muscle
General
carbonic anhydrase (dehydratase)
glycoprotein
membrane protein
metalloprotein
Properties
SIZE: entity length = 337 aa
MW = 38 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-15}
Zn+2-binding site
SITE: 109-109
Zn+2-binding site
SITE: 111-111
Zn+2-binding site
SITE: 135-135
N-glycosylation site {N213}
transmembrane domain {291-311}
Database Correlations
OMIM 604832
UniProt Q9ULX7
Pfam PF00194
Entrez Gene 23632
Kegg hsa:2363
ENZYME 4.2.1.1
References
UniProt :accession Q9ULX7