carbinoxamine/pseudoephedrine (Carbiset, Rondec)

Tradenames: Carbiset, Rondec. Indications: 1) seasonal allergic rhinitis 2) urticaria Contraindications: 1) narrow-angle glaucoma 2) bladder neck obstruction 3) symptomatic prostatic hypertrophy 4) stenosing peptic ulcer 5) concurrent MAO inhibitor therapy Caution: patients with hypertension Dosage: 1) adults: 1 tablet or 5 mL syrup QID 2) children: a) 18 months-6 years: 2.5 mL syrup TID-QID b) > 6 years: 5 mL syrup BID-QID Tablets: carbinoxamine maleate 4 mg + pseudoephedrine HCl 60 mL Syrup: carbinoxamine maleate 4 mg + pseudoephedrine HCl 60 mL/5mL (240 mL) Adverse effects: 1) common (> 10%) - drowsiness - thickening of bronchial secretions 2) less common (1-10%) - headache, fatigue, increased appetite, weight gain, nervousness, dizziness, nausea, diarrhea, abdominal pain, dry mouth, pharyngitis, arthralgia 3) uncommon (< 1%) - angioedema, bronchospasm, depression, edema, epistaxis, hepatitis, myalgia, palpitations, paresthesias, photosensitivity, rash

General

pharmacologic combination decongestant

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

carbinoxamine; rotaxamine (Allergefon, Lergefin, Ciberon, Clistin, Rotoxamina) pseudoephedrine (Sudafed, Afrin, Drixoral, SudoGest)