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cannabinoid receptor 1; CB1; CB-R; CANN6 (CNR1, CNR)
Function:
- role in cannabinoid-induced CNS effects
- endogenous ligand is anandamide
- coupled to Gi & pertussis toxin-sensitive G protein that inhibits N-type Ca+2 channel
- isoform 2 & isoform 3 have altered ligand binding
- interacts (via C-terminus) with CNRIP1
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=3
Expression: widely expressed
Pharmacology: rimonabant is antagonist
Related
rimonabant (Acomplia, Zimulti)
General
cannabinoid receptor
glycoprotein
Properties
SIZE: MW = 53 kD
entity length = 472 aa
COMPARTMENT: plasma membrane
CELL: unspecified cell type
WITHIN: brain
unspecified cell type
WITHIN: testis
MOTIF: exoplasmic domain {1-116}
MOTIF: N-glycosylation site {N77}
N-glycosylation site {N83}
N-glycosylation site {N112}
transmembrane domain {117-142}
cytoplasmic loop {143-154}
transmembrane domain {155-175}
exoplasmic loop {176-187}
transmembrane domain {188-212}
cytoplasmic loop {213-232}
transmembrane domain {233-255}
exoplasmic loop {256-273}
transmembrane domain {274-299}
cytoplasmic loop {300-344}
transmembrane domain {345-365}
exoplasmic loop {366-377}
transmembrane domain {378-399}
cytoplasmic domain {400-472}
Database Correlations
OMIM 114610
UniProt P21554
Entrez Gene 1268
References
- Matsuda et al
Structure of a cannabinoid receptor and functional expression
of the cloned cDNA.
Nature 346:561 1990
PMID: 2165569
- Devane WA
New dawn of cannabinoid pharmacology.
TIPS 15:40 1994
PMID: 8165721