cAMP responsive element-binding protein 3-like protein 4 (androgen-induced basic leucine zipper protein, AIbZIP, cyclic AMP-responsive element-binding protein 4, attaching to CRE-like 1, ATCE1, transcript induced in spermiogenesis protein 40, Tisp40, hJAL, CREB3L4, AIBZIP, CREB4, JAL)

Function: 1) transcriptional activator 2) may play a role in the unfolded protein response 3) binds to the UPR element (UPRE) but not to CRE element 4) preferentially binds to DNA consensus sequence 5'-T[GT]ACGT[GA][GT]-3' 5) has transcriptional activation activity from UPRE 6) binds to NF-kappa-B site & has transcriptional activation activity from NF-kappa-B-containing regulatory elements 7) binds DNA as a dimer 8) controlled by regulated intramembrane proteolysis 9) following ER stress, a fragment containing the cytoplasmic transcription factor domain is released by proteolysis Structure: - N-glycosylated in the C-terminal region - belongs to the bZIP family. ATF subfamily. - contains 1 bZIP domain Compartment: - endoplasmic reticulum membrane - processed form: nucleus - under ER stress, cleaved N-terminal cytoplasmic domain translocates into nucleus - may also be located in Golgi apparatus Expression: - expressed in prostate - expressed in prostatic luminal epithelial cells - also expressed in brain, pancreas, skeletal muscle > small intestine, testis, leukocyte & thymus - induced by androgens Pathology: - expressed in breast & prostate cancer cell lines - expression is significantly more abundant in prostate cancer than in benign prostatic hyperplasia

General

basic leucine zipper (bZIP) family protein DNA-binding protein glycoprotein membrane protein transcription factor (TF)

Properties

SIZE: MW = 43 kD entity length = 395 aa COMPARTMENT: cytoplasm cell nucleus golgi endoplasmic reticulum MOTIF: DNA-binding motif SITE: 219-239 leucine zipper SITE: 245-280 FOR-BINDING-VIA: leucine zipper transmembrane domain {296-316} proteolytic site {338-339} N-glycosylation site {N366}

Database Correlations

OMIM correlations UniProt Q8TEY5 Pfam PF00170

References

UniProt :accession Q8TEY5