cAMP responsive element-binding protein 3-like protein 3 (transcription factor CREB-H, CREB3L3, CREBH, HYST1481)

Function: - transcription factor - may act during endoplasmic reticulum stress via activating unfolded protein response target genes - activated in response to cAMP stimulation - in vitro, binds to the cAMP response element (CRE) & box-B element - activates transcription through box-B element - activates transcription through CRE - functions synergistically with ATF6 - in acute inflammatory response, may activate expression of acute phase response (APR) genes - role in growth suppression (putative) - binds DNA as a dimer - homodimerizes - forms a heterodimer with ATF6 - interacts with ATF6 - controlled by regulated intramembrane proteolysis - following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis Structure: - belongs to the bZIP family, ATF subfamily - contains 1 bZIP domain Compartment: - endoplasmic reticulum membrane - single-pass type II membrane protein - processed form: nucleus - under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus Alternative splicing: named isoforms=3 Expression: - exclusively expressed in liver - underexpressed in hepatocellular carcinoma tissues

General

DNA-binding protein glycoprotein membrane protein transcription factor (TF)

Properties

SIZE: MW = 49 kD entity length = 461 aa COMPARTMENT: cytoplasm cell nucleus endoplasmic reticulum MOTIF: DNA-binding motif SITE: 245-265 leucine zipper SITE: 271-306 FOR-BINDING-VIA: leucine zipper transmembrane domain {323-343} proteolytic site {363-364} N-glycosylation site {N410} N-glycosylation site {N413} N-glycosylation site {N420} N-glycosylation site {N427}

Database Correlations

UniProt Q68CJ9 Pfam PF00170

References

UniProt :accession Q68CJ9