cAMP responsive element-binding protein 3-like protein 1 (OASIS, CREB3L1, PSEC0238)

Function: - franscription factor - acts during endoplasmic reticulum stress by activating unfolded protein response target genes - specifically involved in ER-stress response in astrocytes in the central nervous system - role in gliosis - in vitro, binds to box-B element, cAMP response element (CRE) & CRE-like sequences, & activates transcription through box-B element but not through CRE Structure: - belongs to the bZIP family, ATF subfamily - contains 1 bZIP domain Compartment: - endoplasmic reticulum membrane - processed form: nucleus - under ER stress the cleaved N-terminal cytoplasmic domain translocates into nucleus - controlled by regulated intramembrane proteolysis - following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis cleavage is performed sequentially by site-1 & site-2 proteases & is triggered by translocation to Golgi Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - high levels in pancreas & prostate - expressed at relatively lower levels in brain

General

basic leucine zipper (bZIP) family protein glycoprotein membrane protein

Properties

SIZE: MW = 57 kD entity length = 519 aa COMPARTMENT: cytoplasm cell nucleus endoplasmic reticulum MOTIF: required for transcriptional activation {1-60} alanine-rich region {146-154} MOTIF: alanine residue (SEVERAL) DNA-binding motif SITE: 292-312 leucine zipper SITE: 318-353 FOR-BINDING-VIA: leucine zipper transmembrane domain {375-395} proteolytic site {426-427} N-glycosylation site {N492} N-glycosylation site {N513}

Database Correlations

UniProt Q96BA8 Pfam PF00170

References

UniProt :accession Q96BA8