calumenin; crocalbin; IEF SSP 9302 (CALU)

Function: - role in regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues - seems to inhibit gamma-carboxylase GGCX - binds 7 Ca⁺² with a low affinity (putative) - interacts with GGCX (putative) Structure: - belongs to the CREC family - contains 6 EF-hand domains Compartment: - endoplasmic reticulum lumen - secreted - melanosome: stages 1-4 - sarcoplasmic reticulum lumen (putative) Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - expressed at high levels in heart, placenta & skeletal muscle - expressed at lower levels in lung, kidney & pancreas - expressed at very low levels in brain & liver

General

Ca+2 binding protein glycoprotein phosphoprotein

Properties

SIZE: entity length = 315 aa MW = 37 kD COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-19} Ser phosphorylation site {S35} Ser phosphorylation site {S44} Thr phosphorylation site {T65} EF hand SITE: 68-103 MOTIF: Ca+2-binding site SITE: 81-92 EF hand SITE: 104-139 MOTIF: Ca+2-binding site SITE: 117-128 N-glycosylation site {N131} EF hand SITE: 151-186 MOTIF: Ca+2-binding site SITE: 164-175 EF hand SITE: 188-223 MOTIF: Ca+2-binding site SITE: 201-212 EF hand SITE: 229-264 MOTIF: Ca+2-binding site SITE: 242-253 EF hand SITE: 265-300 MOTIF: Ca+2-binding site SITE: 278-289 ER retention {312-315}

Database Correlations

OMIM 603420 UniProt O43852 Entrez Gene 813 Kegg hsa:813