calprotectin complex (S100A8/A9)

Function: - extracellular calprotectin binds to target cells & promotes apoptosis - interacts with ANXA6 & associates with tubulin filaments in activated monocytes Structure: - subunits: S100A8, S100A9; heterotetramer, 2 copies of each Compartment: - extracellular Laboratory: - serum S100A8/A9 may be useful as a marker of inflammation & in the diagnosis of acute appendicitis Pathology: - calprotectin is shed in the stool of patients with inflammatory bowel disease (see calprotectin in stool)

Related

calprotectin in stool (S100A8/A9 in stool) S100A8/A9 in serum (calprotectin in serum)

Properties

SUBUNITS: protein S100-A8 (2) COMPARTMENT: cytoplasm MOTIF: EF hand SITE: 12-47 MOTIF: Ca+2-binding site SITE: 20-33 EF hand SITE: 46-81 MOTIF: Ca+2-binding site SITE: 59-70 SECRETED-BY: neutrophil protein S100-A9 (2) COMPARTMENT: cytoplasm MOTIF: EF hand SITE: 12-47 MOTIF: Ca+2-binding site SITE: 23-36 EF hand SITE: 54-89 MOTIF: Ca+2-binding site SITE: 67-78 Thr phosphorylation site {T113} SECRETED-BY: neutrophil

References

UniProt :accession P05109

Components

protein S100-A8; S100 Ca+2-binding protein A8; calgranulin-A; migration inhibitory factor-related protein 8; MRP-8; p8; Cystic fibrosis antigen; CFAG; Leukocyte L1 complex light chain; calprotectin L1L subunit; urinary stone protein band A (S100A8, CAGA, CFAG, MRP8) protein S100-A9; S100 Ca+2-binding protein A9; calgranulin-B; migration inhibitory factor-related protein 14; MRP-14; p14; Leukocyte L1 complex heavy chain; calprotectin L1H subunit (S100A9, CAGB, CFAG, MRP14)