calponin-2; calponin H2, smooth muscle; neutral calponin (CNN2)

Function: - thin filament-associated protein implicated in regulation & modulation of smooth muscle contraction - capable of binding to actin, calmodulin, troponin C & tropomyosin - interaction of calponin with actin inhibits actomyosin Mg-ATPase activity Structure: - belongs to the calponin family - contains 3 calponin-like repeats - contains 1 CH (calponin-homology) domain Expression: - expressed in heart & smooth muscle

General

calponin phosphoprotein

Properties

SIZE: entity length = 309 aa MW = 34 kD COMPARTMENT: cytoplasm MOTIF: calponin homology domain NAME: calponin homology domain SITE: 28-131 Calponin-like {166-191} MOTIF: Tyr phosphorylation site {Y184} Calponin-like {206-231} Calponin-like {245-269}

Database Correlations

OMIM 602373 UniProt Q99439 PFAM correlations Entrez Gene 1265 Kegg hsa:1265

References

UniProt :accession Q99439