calmodulin-binding transcription activator 2 (CAMTA2, KIAA0909)

Function: 1) transcription activator 2) may act as tumor suppressor. 3) interacts with calmodulin (putative) Structure: - belongs to the CAMTA family - contains 3 ANK repeats - contains 1 CG-1 DNA-binding domain - contains 1 IPT/TIG domain - contains 2 IQ domains Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - expressed in brain - expressed at constant levels throughout the cell cycle in neuroblastoma cell lines

General

anti-oncoprotein (tumor suppressor protein) calmodulin binding protein DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 132 kD entity length = 1202 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 65-182 MOTIF: nuclear translocation signal {79-86} serine-rich region {289-300} MOTIF: serine residue (SEVERAL) IPT/TIG {535-617} ankyrin repeat NAME: ankyrin repeat SITE: 712-745 ankyrin repeat NAME: ankyrin repeat SITE: 757-787 ankyrin repeat NAME: ankyrin repeat SITE: 791-821 IQ motif {1049-1078} IQ motif {1102-1131}

Database Correlations

UniProt O94983 PFAM correlations

References

UniProt :accession O94983