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calicin (CCIN)
Function:
- possible morphogenetic cytoskeletal element in spermiogenic differentiation
Structure:
- contains 1 BACK (BTB/kelch associated) domain
- contains 1 BTB/POZ domain
- contains 6 kelch repeats
Compartment:
- cytoplasm, cytoskeleton, perinuclear theca, calyx
- sperm head cytoskeletal structure tightly associated with the nucleus
Expression:
- testis
- not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa
General
cytoskeletal protein
Properties
SIZE: entity length = 588 aa
MW = 67 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: BTB domain {12-124}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
BACK {133-235}
kelch repeat {280-327}
kelch repeat {328-375}
kelch repeat {377-423}
kelch repeat {425-475}
kelch repeat {476-525}
kelch repeat {526-580}
Database Correlations
OMIM 603960
UniProt Q13939
PFAM correlations
Entrez Gene 881
Kegg hsa:881
References
UniProt :accession Q13939