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calcyclin-binding protein (CacyBP, hCacyBP, Siah-interacting protein, S100A6-binding protein, CACYBP, S100A6BP, SIP, PNAS-107)
Function:
1) involved in Ca+2-dependent ubiquitination & subsequent proteosomal degradation of target proteins
2) serves as a molecular bridge in ubiquitin E3 complexes
3) ubiquitin-mediated degradation of beta-catenin
4) interacts with proteins of the S100 family: S100A1, S100A6, S100B, S100P, S100A12
5) component of some large E3 complex
6) interacts directly with SIAH1, SIAH2, SKP1A
7) phosphorylated on Ser
8) phosphorylated upon induction by retinoic acid or at high Ca+2
9) at low Ca+2 concentrations, nuclear fraction may be phosphorylated
Compartment: nucleus, cytoplasm
Alternative splicing: named isoforms=2
Interactions
molecular events
General
other protein
Properties
SIZE: MW = 26 kD
entity length = 228 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 1-80
FOR-BINDING-OF: E3 ubiquitin-protein ligase SIAH1
CS {73-167}
binding site
SITE: 73-228
FOR-BINDING-OF: S-phase kinase-associated protein 1
MOTIF: binding site
SITE: 154-228
FOR-BINDING-OF: protein S100-A6
SGS {168-228}
Database Correlations
OMIM 606186
UniProt Q9HB71
PFAM correlations
References
- UniProt :accession Q9HB71
- Matsuzawa SI & Reed JC
Siah-1, SIP, and Ebi collaborate in a novel pathway for
beta-catenin degradation linked to p53 responses.
Molecular Cell 7:915-26, 2001
PMID: 11389839
Component-of
molecular complex