calcitonin receptor; CT-R (CALCR)

Function: - receptor for calcitonin - activity is mediated by G proteins which activate adenylyl cyclase (Gs proteins) - thought to couple to the Gs protein that is sensitive to cholera toxin - interacts with GPRASP2 Structure: belongs to the G-protein coupled receptor 2 family Compartment: cell membrane Alternative splicing: named isoforms=3 Polymorphism: - genetic variations in CALCR may be correlated with low bone mineral density, osteoporosis

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 490 aa MW = 57 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-24} exoplasmic domain {25-153} MOTIF: N-glycosylation site {N28} N-glycosylation site {N73} N-glycosylation site {N125} N-glycosylation site {N130} transmembrane domain {154-173} cytoplasmic loop {174-196} transmembrane domain {197-216} exoplasmic loop {217-236} transmembrane domain {237-259} cytoplasmic loop {260-276} transmembrane domain {277-296} exoplasmic loop {297-312} transmembrane domain {313-336} cytoplasmic loop {337-359} transmembrane domain {360-377} exoplasmic loop {378-389} transmembrane domain {390-411} cytoplasmic domain {412-490} MOTIF: alanine-rich region {444-449} MOTIF: alanine residue (SEVERAL)

Database Correlations

OMIM 114131 MORBIDMAP 114131 UniProt P30988 PFAM correlations Entrez Gene 799 Kegg hsa:799

References

UniProt :accession P30988