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calcitonin; contains: katacalcin; calcitonin carboxyl-terminal peptide; CCP; PDN-21 (CALC, CALC1)
Function:
1) inhibits osteoclastic bone resorption
a) effect is largely on trabecular bone, not cortical bone
b) decreases risk of vertebral fractures, not hip fractures
2) lowers serum Ca+2 concentrations
- causes a rapid but short-lived drop in the level of Ca+2 & phosphate in plasma by promoting the incorporation of these ions into bone
3) calcitonin also has analgesic properties
Structure: belongs to the calcitonin family
Compartment: secreted
Alternative splicing:
- named isoforms=3
- at least one isoform produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- produced in humans primarily by the parafollicular C-cells of the thyroid [4]
Pharmacology: see Cibacalcin (Calcimar, Miacalcin)
Laboratory:
- calcitonin measurement
- calcitonin in lymph node
- calcitonin in serum
- calcitonin Ag in tissue
Related
calcitonin in serum
calcitonin receptor; CT-R (CALCR)
calcitonin/alpha CGRP gene or CALC1
osteoporosis
Paget's disease of the bone; osteitis deformans
procalcitonin in serum (Vidas Brahms PCT Assay)
Specific
Calcitonin Nasal
Calcitonin Parenteral
katacalcin
procalcitonin; contains: calcitonin, katacalcin; calcitonin carboxyl-terminal peptide; CCP; PDN-21 (CALCA, CALC1)
salmon calcitonin (Cibacalcin, Calcimar, Miacalcin)
General
secreted protein
thyroid hormone
Properties
SIZE: entity length = 141 aa
MW = 15 kD
COMPARTMENT: extracellular compartment
SECRETED-BY: parafollicular cell
WITHIN: thyroid
MOTIF: cysteine residue {C85}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C85}
MISC-INFO: elimination route PLASMA
1/2life 1 HOURS
pregnancy-category C
safety in lactation ?
Database Correlations
OMIM 114130
UniProt P01258
Pfam PF00214
Entrez Gene 796
Kegg hsa:796
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Felsenfeld AJ and Levine BS.
Calcitonin, the forgotten hormone: does it deserve to be forgotten?
Clin Kidney J. 2015 Apr;8(2):180-7.
PMID: 25815174
- UCLA Intensive Course in Geriatric Medicine & Board Review,
Marina Del Ray, CA, Sept 12-15, 2001
- UniProt :accession P01258
- NIEHS-SNPs
http://egp.gs.washington.edu/data/calca/
- Wikipedia; Note: calcitonin entry
http://en.wikipedia.org/wiki/calcitonin