protocadherin fat 1; cadherin-related tumor suppressor homolog; protein fat homolog; cadherin family member 7 (FAT1, CDHF7, FAT)

Function: - could function as a cell-adhesion protein - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 34 cadherin domains - contains 5 EGF-like domains - contains 1 laminin G-like domain Compartment: - cell membrane; single-pass type 1 membrane protein (putative) Expression: - expressed in many epithelial cells, ome endothelial cells & smooth muscle cells

Related

cadherin protocadherin fat 2; hfat2; multiple epidermal growth factor-like domains protein 1; multiple EGF-like domains protein 1; cadherin family member 8 (FAT2, CDHF8, KIAA0811, MEGF1)

General

adhesion receptor glycoprotein phosphoprotein

Properties

SIZE: entity length = 4590 aa MW = 506 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-21} cadherin domain {22-149} MOTIF: N-glycosylation site {N40} cadherin domain {150-256} MOTIF: Thr phosphorylation site {T152} cadherin domain {257-361} MOTIF: N-glycosylation site {N333} cadherin domain {362-463} cadherin domain {464-569} MOTIF: Thr phosphorylation site {T464} Tyr phosphorylation site {Y468} cadherin domain {570-716} MOTIF: N-glycosylation site {N660} cadherin domain {717-822} MOTIF: N-glycosylation site {N740} N-glycosylation site {N791} cadherin domain {823-927} cadherin domain {928-1034} MOTIF: N-glycosylation site {N998} cadherin domain {1035-1138} cadherin domain {1139-1245} cadherin domain {1246-1345} cadherin domain {1346-1456} MOTIF: N-glycosylation site {N1426} cadherin domain {1457-1562} MOTIF: N-glycosylation site {N1551} cadherin domain {1563-1670} cadherin domain {1671-1769} MOTIF: N-glycosylation site {N1751} cadherin domain {1770-1882} MOTIF: N-glycosylation site {N1867} cadherin domain {1883-1982} MOTIF: N-glycosylation site {N1905} N-glycosylation site {N1943} cadherin domain {1983-2084} MOTIF: N-glycosylation site {N1994} cadherin domain {2085-2185} cadherin domain {2186-2286} cadherin domain {2287-2393} MOTIF: N-glycosylation site {N2328} cadherin domain {2394-2495} MOTIF: N-glycosylation site {N2467} cadherin domain {2496-2599} cadherin domain {2600-2705} MOTIF: Tyr phosphorylation site {Y2604} Ser phosphorylation site {S2611} Thr phosphorylation site {T2616} cadherin domain {2706-2811} cadherin domain {2812-2920} cadherin domain {2921-3024} cadherin domain {3025-3127} cadherin domain {3128-3232} cadherin domain {3233-3337} MOTIF: N-glycosylation site {N3326} cadherin domain {3338-3442} MOTIF: N-glycosylation site {N3417} N-glycosylation site {N3424} cadherin domain {3443-3546} MOTIF: N-glycosylation site {N3446} cadherin domain {3547-3649} MOTIF: N-glycosylation site {N3615} N-glycosylation site {N3642} N-glycosylation site {N3718} EGF domain {3790-3827} MOTIF: cysteine residue {C3796} MODIFICATION: cysteine residue {C3807} cysteine residue {C3801} MODIFICATION: cysteine residue {C3818} cysteine residue {C3807} MODIFICATION: cysteine residue {C3796} cysteine residue {C3818} MODIFICATION: cysteine residue {C3801} cysteine residue {C3820} MODIFICATION: cysteine residue {C3828} cysteine residue {C3828} MODIFICATION: cysteine residue {C3820} Laminin G-like {3831-4011} MOTIF: cysteine residue {C3978} MODIFICATION: cysteine residue {C4011} cysteine residue {C4011} MODIFICATION: cysteine residue {C3978} EGF domain {4013-4051} MOTIF: cysteine residue {C4019} MODIFICATION: cysteine residue {C4030} cysteine residue {C4024} MODIFICATION: cysteine residue {C4040} cysteine residue {C4030} MODIFICATION: cysteine residue {C4019} cysteine residue {C4040} MODIFICATION: cysteine residue {C4024} cysteine residue {C4042} MODIFICATION: cysteine residue {C4051} cysteine residue {C4051} MODIFICATION: cysteine residue {C4042} EGF domain {4052-4089} MOTIF: cysteine residue {C4058} MODIFICATION: cysteine residue {C4069} cysteine residue {C4063} MODIFICATION: cysteine residue {C4078} cysteine residue {C4069} MODIFICATION: cysteine residue {C4058} cysteine residue {C4078} MODIFICATION: cysteine residue {C4063} cysteine residue {C4080} MODIFICATION: cysteine residue {C4089} cysteine residue {C4089} MODIFICATION: cysteine residue {C4080} EGF domain {4090-4126} MOTIF: cysteine residue {C4095} MODIFICATION: cysteine residue {C4106} cysteine residue {C4100} MODIFICATION: cysteine residue {C4115} cysteine residue {C4106} MODIFICATION: cysteine residue {C4095} cysteine residue {C4115} MODIFICATION: cysteine residue {C4100} cysteine residue {C4117} MODIFICATION: cysteine residue {C4126} cysteine residue {C4126} MODIFICATION: cysteine residue {C4117} EGF domain {4127-4163} MOTIF: cysteine residue {C4133} MODIFICATION: cysteine residue {C4144} cysteine residue {C4138} MODIFICATION: cysteine residue {C4153} cysteine residue {C4144} MODIFICATION: cysteine residue {C4133} cysteine residue {C4153} MODIFICATION: cysteine residue {C4138} N-glycosylation site {N4154} cysteine residue {C4155} MODIFICATION: cysteine residue {C4164} cysteine residue {C4164} MODIFICATION: cysteine residue {C4155} transmembrane domain {4184-4204} Ser phosphorylation site {S4274}

Database Correlations

OMIM 600976 UniProt Q14517 PFAM correlations Entrez Gene 2195 Kegg hsa:2195

References

UniProt :accession Q14517