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cadherin-17; liver-intestine cadherin; LI-cadherin; intestinal peptide-associated transporter HPT-1 (CDH17)
Function:
- cadherin
- may have a role in the morphological organization of liver & intestine
- role in intestinal peptide transport
Structure: contains 7 cadherin domains
Compartment: cell membrane
Expression:
- expressed in the gastrointestinal tract & pancreatic duct
- not detected in kidney, lung, liver, brain, adrenal gland & skin
General
cadherin
glycoprotein
phosphoprotein
Properties
SIZE: MW = 92 kD
entity length = 832 aa
COMPARTMENT: cellular membrane
MOTIF: cadherin domain {30-128}
cadherin domain {129-244}
MOTIF: N-glycosylation site {N149}
N-glycosylation site {N184}
cadherin domain {245-340}
MOTIF: N-glycosylation site {N250}
cadherin domain {341-449}
MOTIF: N-glycosylation site {N419}
binding site
FOR-BINDING-OF: catenin
phosphorylation site
cadherin domain {450-566}
MOTIF: N-glycosylation site {N456}
N-glycosylation site {N546}
cadherin domain {567-667}
MOTIF: N-glycosylation site {N587}
Ca+2-binding site
SITE: C-TERMINAL
cadherin domain {668-777}
MOTIF: N-glycosylation site {N722}
transmembrane domain {788-808}
Database Correlations
OMIM 603017
UniProt Q12864
Pfam PF00028
Entrez Gene 1015
Kegg hsa:1015
References
- Entrez Gene :accession 1015
- UniProt :accession Q12864