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cadherin-11; osteoblast cadherin; OB-cadherin; OSF-4 (CDH11)
Function:
- cadherin
Structure: contains 5 cadherin domains
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- expressed mainly in brain but also found in other tissues
- expressed in neuroblasts
- expressed in synovial cells
Pathology:
- cadherin-11 on the surface of synovial cells triggers inflammation & synovial proliferation in rheumatoid arthritis (see pathology of rheumatoid arthritis)
Related
osteoblast
rheumatoid arthritis (RA)
General
cadherin
glycoprotein
Properties
SIZE: MW = 88 kD
entity length = 796 aa
COMPARTMENT: plasma membrane
CELL: osteoblast
MOTIF: signal sequence {1-22}
cadherin domain {54-159}
cadherin domain {160-268}
cadherin domain {269-383}
cadherin domain {384-486}
MOTIF: N-glycosylation site {N455}
binding site
FOR-BINDING-OF: catenin
cadherin domain {487-612}
MOTIF: N-glycosylation site {N540}
Ca+2-binding site
SITE: C-TERMINAL
transmembrane domain {618-640}
Database Correlations
OMIM 600023
UniProt P55287
PFAM correlations
Entrez Gene 1009
Kegg hsa:1009
References
- OMIM :accession 600023
- Entrez Gene :accession 1009
- UniProt :accession P55287