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CABLES1/PCTK1/PCTK2/TDRD7 complex


General

molecular complex

Properties

COMPARTMENT: endosome SUBUNITS: CDK5 & ABL1 enzyme substrate 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: TDRD7 interaction {1-109} alanine-rich region {2-134} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S168} CDK3 interaction {179-492} MOTIF: Ser phosphorylation site {S242} Ser phosphorylation site {S287} Ser phosphorylation site {S290} Ser phosphorylation site {S291} Thr phosphorylation site {T294} Ser phosphorylation site {S311} Ser phosphorylation site {S313} Ser phosphorylation site {S373} Thr phosphorylation site {T415} Ser phosphorylation site {S418} Thr phosphorylation site {T419} Ser phosphorylation site {S421} Ser phosphorylation site {S434} Ser phosphorylation site {S439} cyclin-dependent kinase-16 STATE: active state MOTIF: Ser phosphorylation site {S12} Ser phosphorylation site {S36} Ser phosphorylation site {S42} Ser phosphorylation site {S65} Ser phosphorylation site {S78} Ser phosphorylation site {S82} Ser phosphorylation site {S95} Ser phosphorylation site {S110} Ser phosphorylation site {S119} Ser phosphorylation site {S138} Ser phosphorylation site {S153} Ser phosphorylation site {S155} kinase domain SITE: 165-446 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 171-179 Tyr phosphorylation site {Y176} ATP-binding site NAME: ATP-binding site SITE: 194-194 aspartate residue {D286} Ser phosphorylation site {S480} cyclin-dependent kinase-17 STATE: active state MOTIF: Ser phosphorylation site {S9} Ser phosphorylation site {S105} Ser phosphorylation site {S122} Ser phosphorylation site {S137} Ser phosphorylation site {S146} Ser phosphorylation site {S165} Ser phosphorylation site {S180} kinase domain SITE: 192-473 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 198-206 Tyr phosphorylation site {Y203} Thr phosphorylation site {T205} ATP-binding site NAME: ATP-binding site SITE: 221-221 aspartate residue {D313} Ser phosphorylation site {S520} tudor domain-containing protein 7 COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: HTH OST-type 1 {3-76} HTH OST-type 2 {233-302} Ser phosphorylation site {S319} HTH OST-type 3 {337-406} Tudor domain SITE: 513-570 Tudor domain SITE: 703-760 CDK17 interaction {861-1098} MOTIF: Ser phosphorylation site {S862} binding site SITE: 893-1098 FOR-BINDING-OF: CDK5 & ABL1 enzyme substrate 1

References

  1. UniProt :accession Q8NHU6

Components

CDK5 & ABL1 enzyme substrate 1; interactor with CDK3 1; Ik3-1 (CABLES1 CABLES) cyclin-dependent kinase-16 (CDK16); serine/threonine protein kinase PCTAIRE-1; PCTAIRE-motif protein kinase 1 (PCTK1) cyclin-dependent kinase-17 (CDK17); serine/threonine protein kinase PCTAIRE-2; PCTAIRE-motif protein kinase 2 (PCTK2) tudor domain-containing protein 7; PCTAIRE2-binding protein; tudor repeat associator with PCTAIRE 2; trap (TDRD7, PCTAIRE2BP)