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calcineurin-binding protein cabin-1; calcineurin inhibitor; CAIN (CABIN1, KIAA0330)
Function:
- may be required for replication-independent chromatin assembly
- may serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin
- binds to & inhibits phosphatase activity of calcineurin
- inhibition of activated calcineurin is dependent on both PKC & Ca+2 signals
- activated through PKC-mediated hyperphosphorylation
- phosphorylated upon DNA damage, probably by ATM or ATR
- component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 & UBN1
- interacts with calcineurin
- interacts with MEF2B
Structure:
- contains 6 TPR repeats
Compartment:
- nucleus
Expression:
- widely expressed in different tissues
Interactions
molecular events
General
calcineurin inhibitor
nuclear protein
PEST protein
Properties
SIZE: entity length = 2220 aa
MW = 246 kD
COMPARTMENT: cell nucleus
MOTIF: tetratricopeptide repeat {36-69}
tetratricopeptide repeat {90-123}
tetratricopeptide repeat {125-157}
tetratricopeptide repeat {615-648}
tetratricopeptide repeat {1055-1088}
tetratricopeptide repeat {1106-1139}
Thr phosphorylation site {T2089}
calcineurin interaction {2116-2153}
Database Correlations
OMIM 604251
UniProt Q9Y6J0
Pfam PF09047
Entrez Gene 23523
Kegg hsa:23523
References
- UniProt :accession Q9Y6J0
- Sun L et al
Cabin 1, a negative regulator for calcineurin signaling in
T lymphocytes.
Immunity 8:703-11, 1998
PMID: 9655484
Component-of
molecular complex