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carbamylated erythropoietin (CEPO)

Mechanism of action: 1) does NOT bind to erythropoietin receptors on erythrocyte progenitors 2) does NOT stimulate erythropoiesis 3) has same neuroprotective effects as erythropoietin

Interactions

monitor with erythropoietins

General

pharmaceutical growth factor hematologic agent erythropoietin (EPO)

References

  1. - Journal Watch 24(16):129, 2004
    1. Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P, Larsen AK, Helboe L, Christensen S, Pedersen LO, Nielsen M, Torup L, Sager T, Sfacteria A, Erbayraktar S, Erbayraktar Z, Gokmen N, Yilmaz O, Cerami-Hand C, Xie QW, Coleman T, Cerami A, Brines M. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science. 2004 Jul 9;305(5681):239-42. PMID: 15247477
    2. Ehrenreich H. Medicine. A boost for translational neuroscience. Science. 2004 Jul 9;305(5681):184-5. No abstract available. PMID: 15247460