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Ca+2 release-activated Ca+2 channel (CRAC channel)
Function:
1) mediates Ca+2 influx following depletion of intracellular Ca+2 stores
2) channel activation by the Ca+2 sensor, STIM1
3) main pathway for Ca+2 influx in T-cells
- promote the immune response to pathogens by activating transcription factor NFAT
Structure: subunits: CRACM1
Compartment: cell membrane
General
molecular complex
Properties
SUBUNITS: Ca+2 release-activated Ca+2 channel protein 1
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-87}
MOTIF: proline-rich region
SITE: 3-47
MOTIF: proline residue (SEVERAL)
transmembrane domain {88-105}
exoplasmic loop {106-119}
transmembrane domain {120-140}
cytoplasmic loop {141-173}
transmembrane domain {174-194}
exoplasmic loop {195-234}
MOTIF: N-glycosylation site {N223}
transmembrane domain {235-255}
cytoplasmic domain {256-301}
References
UniProt :accession Q96D31
Components
Ca+2 release-activated Ca+2 channel protein 1 (transmembrane protein 142A, protein orai-1, TMEM142A, CRACM1, ORAI1)