Ca+2-binding & coiled-coil domain-containing protein 2 (nuclear domain 10 protein NDP52, nuclear domain 10 protein 52, nuclear dot protein 52, antigen nuclear dot 52 kD protein, CALCOCO2, NDP52)

Function: - may play a role in ruffle formation & actin cytoskeleton organization - seems to negatively regulate constitutive secretion - part of a complex consisting of CALCOCO2, TAX1BP1 & MYO6 - interacts with GEMIN4 Compartment: - cytoplasm, perinuclear region, Golgi Expression: - expressed in all tissues tested - highest expression in skeletal muscle - lowest expression in brain

General

Ca+2 binding protein cytoskeletal protein

Properties

SIZE: entity length = 446 aa MW = 52 kD COMPARTMENT: cytoplasm cell nucleus golgi MOTIF: Ca+2-binding site coiled coil {137-349} MYO6 interaction {395-446}

Database Correlations

OMIM 604587 UniProt Q13137 Pfam PF07888

References

UniProt :accession Q13137