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Ca+2-activated chloride channel regulator 4; Ca+2-activated chloride channel family member 4; hCLCA4; Ca+2-activated chloride channel protein 2; CaCC-2; hCaCC-2; contains: Ca+2-activated chloride channel regulator 4, 110 kD form, Ca+2-activated chloride channel regulator 4, 30 kD form (CLCA4, CaCC2, UNQ562/PRO1124)
Function:
- may be involved in mediating Ca+2-activated chloride conductance
- processed at a monobasic residue to yield a larger N-terminal & a smaller C-terminal cleavage products of 90 to 110 & 30 to 35 kD, respectively (putative)
Structure:
- N-glycosylated (putative)
- belongs to the CLCR family
- contains 1 VWFA domain
Compartment:
- cell membrane
- apical cell membrane
- secreted (putative)
- the C-terminus 30 kD form is anchored to the membrane (putative)
- the N-terminus 110 kD form is released from the membrane triggered by an unknown stimulus
Expression:
- primarily expressed in the digestive tract, mainly in colon
- detected in smaller amounts in brain, urogenital organs, testis, & salivary & mammary glands
- highly expressed in the epithelial layer & submucosal gland of the inferior turbinate mucosa
- lower levels in the epithelial layer of nasal polyp
Pathology:
- down-regulated in oral tongue squamous cell carcinomas
General
glycoprotein
membrane protein
Properties
SIZE: entity length = 919 aa
MW = 101 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
N-glycosylation site {N75}
VWFA domain {306-476}
MOTIF: N-glycosylation site {N340}
N-glycosylation site {N504}
N-glycosylation site {N542}
N-glycosylation site {N588}
N-glycosylation site {N628}
N-glycosylation site {N811}
N-glycosylation site {N832}
N-glycosylation site {N837}
N-glycosylation site {N852}
transmembrane domain {895-915}
Database Correlations
UniProt Q14CN2
PFAM correlations
Kegg hsa:2280
References
UniProt :accession Q14CN2