Ca+2-activated chloride channel regulator 1 (Ca+2-activated chloride channel family member 1, hCLCA1, hCaCC-1, CLCA1 CACC1)

Function: - may be involved in mediating Ca⁺²-activated chloride conductance - may play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis & airway hyper- reactivity - may be involved in the regulation of mucus production &/or secretion by goblet cells - involved in the regulation of tissue inflammation in the innate immune response - may play a role as a tumor suppressor induces MUC5AC Structure: - glycosylated - the 125-kD product is processed & yields to two cell- surface-associated subunits, a 90-kD protein & a group of 37-41 kD proteins - belongs to the CLCR family - contains 1 VWFA domain Compartment: - secreted, extracellular space, cell membrane - peripheral membrane, extracellular side - protein that remains attached to the plasma membrane appears to be predominantly localized to microvilli Expression: - highly expressed in small intestine & colon a) intestinal basal crypt epithelia b) goblet cells c) appendix - weakly expressed in uterus, testis & kidney - expressed in the airways epithelium of both asthmatic & healthy patients - expressed in the bronchial epithelium, especially in mucus- producing goblet cells - expressed in normal turbinate mucosa & nasal polyps - induced by IL13 in tracheobronchial epithelial cells - up-regulated by histamine in a dose-dependent manner - significantly increased by TNF in upper airway mucosa Pathology: - down-regulated in colorectal cancer - up-regulated in IL9-responsive mucus-producing epithelium of asthmatic patients - significantly decreased in nasal polyps

General

glycoprotein secreted protein

Properties

SIZE: entity length = 914 aa MW = 100 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} VWFA domain {306-475} N-glycosylation site {N503} N-glycosylation site {N585}

Database Correlations

OMIM 603906 UniProt A8K7I4 PFAM correlations

References

UniProt :accession A8K7I4