C5-cytosine DNA methyltransferase-2; tRNA (cytosine-5-)-methyltransferase; DNA (cytosine-5)-methyltransferase-like protein 2; Dnmt2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; M.HsaIIP; PuMet (TRDMT1, DNMT2)

Function: - specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine Structure: belongs to the C5-methyltransferase family Compartment: nucleus (probable) Alternative splicing: - named isoforms=6 - additional isoforms seem to exist Expression: - ubiquitous - higher expression in testis, ovary & thymus - expressed at much lower levels in spleen, prostate, colon, small intestine, & peripheral blood leukocytes

General

DNA (cytosine-5)-methyltransferase DNA-binding protein

Properties

SIZE: entity length = 391 aa MW = 45 kD COMPARTMENT: cell nucleus MOTIF: cysteine residue {C79}

Database Correlations

OMIM 602478 UniProt O14717 Pfam PF00145 Entrez Gene 1787 Kegg hsa:1787 ENZYME 2.1.1.29

References

UniProt :accession O14717