Search
complement complex C5b6789 (MAC, Membrane Attack Complex)
Formed on the surface of intruding pathogenic bacteria as a result of the activation of the complement system
Function:
- complement complex that forms osmolytic pore leading to cell lysis (bactericidal)
- multiple copies of complement C9 required for complete formation of the osmolytic pore
- incorporation of C9 inhibited by CD59
Laboratory:
- C5B-9 Ag in tissue
Interactions
molecular events
Related
complement cascade
General
complement complex
Properties
COMPARTMENT: membrane
References
- Wikipedia: Complement membrane attack complex
http://en.wikipedia.org/wiki/Membrane_attack_complex
- Tschopp J et al
Structural/functional similarity between proteins involved in
complement- and cytotoxic T-lymphocyte-mediated cytolysis
Nature 322:831, 1986
PMID: 2427956
Components
complement C5b
complement-6 (C6)
complement-7 (C7)
complement-8 (C8)
complement-9 (C9)