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CD88; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR (C5AR1, C5AR, C5R1)
Function:
- receptor for the chemotactic & inflammatory peptide anaphylatoxin C5a
- couples to G16-alpha, Gi2 & Gi3.
- effector for C5a mediated inflammation
- granulocyte activation
- stimulates chemotaxis, granule enzyme release & superoxide production
- sulfation plays a role in association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal & mobilize Ca+2 in response to a small peptide agonist
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- granulocytes
- monocytes
- dendritic cells
- astrocytes
- microglia
Related
complement C5a
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
complement receptor
glycoprotein
phosphoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 350 aa
MW = 39 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-37}
MOTIF: N-glycosylation site {N5}
transmembrane domain {38-60}
cytoplasmic loop {61-71}
transmembrane domain {72-94}
exoplasmic loop {95-110}
MOTIF: cysteine residue {C109}
MODIFICATION: cysteine residue {C188}
transmembrane domain {111-132}
cytoplasmic loop {133-153}
transmembrane domain {154-174}
exoplasmic loop {175-200}
MOTIF: cysteine residue {C188}
MODIFICATION: cysteine residue {C109}
transmembrane domain {201-226}
cytoplasmic loop {227-242}
transmembrane domain {243-265}
exoplasmic loop {266-282}
transmembrane domain {283-303}
cytoplasmic domain {304-350}
MOTIF: Ser phosphorylation site {S314}
Ser phosphorylation site {S317}
Ser phosphorylation site {S327}
Ser phosphorylation site {S332}
Ser phosphorylation site {S334}
Ser phosphorylation site {S338}
MISC-INFO: Kd [C5A] 17 PM
Database Correlations
OMIM 113995
UniProt P21730
Pfam PF00001
Entrez Gene 728
Kegg hsa:728
References
- UniProt :accession P21730
- Siciliano SJ, Rollins TE, Springer MS.
Interaction between the C5a receptor and Gi in both the
membrane-bound and detergent-solubilized states.
J Biol Chem. 1990 Nov 15;265(32):19568-74.
PMID: 2123189
- http://www.pathologyoutlines.com/cdmarkers.html
20 May 2003
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/666919736_g.htm