C5a anaphylatoxin chemotactic receptor 2; complement component 5a receptor 2; G-protein coupled receptor 77 (C5AR2, C5L2, GPR77)

Function: - receptor for the chemotactic & inflammatory C3a, C4a & C5a anaphylatoxins & for their dearginated forms ASP/C3adesArg, C4adesArg & C5adesArg respectively - couples weakly to Gi-mediated signaling pathways - interacts with C3 (the anaphylatoxin peptide C3a & the adipogenic hormone ASP) - interaction occurs with higher affinity for ASP, enhancing the phosphorylation & activation of GPR77, recruitment of ARRB2 to the cell surface & endocytosis of GRP77 Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed in frontal cortex, hippocampus, hypothalamus, pons, liver

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 36 kD entity length = 337 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-38} MOTIF: N-glycosylation site {N3} transmembrane domain {39-61} cytoplasmic loop {62-72} transmembrane domain {73-95} exoplasmic loop {96-114} MOTIF: cysteine residue {C107} MODIFICATION: cysteine residue {C186} transmembrane domain {115-137} cytoplasmic loop {138-149} transmembrane domain {150-172} exoplasmic loop {173-202} MOTIF: cysteine residue {C186} MODIFICATION: cysteine residue {C107} transmembrane domain {203-225} cytoplasmic loop {226-237} transmembrane domain {238-260} exoplasmic loop {261-274} transmembrane domain {275-294} cytoplasmic domain {295-337}

Database Correlations

OMIM 609949 UniProt Q9P296 Pfam PF00001 Entrez Gene 27202 Kegg hsa:27202

References

UniProt :accession Q9P296