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C3 & PZP-like alpha-2-macroglobulin domain-containing protein 8 (CPAMD8, KIAA1283)
Function:
- interacts with heparin
- appears to be proteolytically cleaved into two chains of about 70 & 130 kDa
Structure:
- belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family
- contains 1 Kazal-like domain
Compartment:
- secreted (putative)
- membrane, plasma membrane-associated
Alternative splicing: named isoforms=2
Expression:
- expressed in the kidney, brain & testis > heart, liver & small intestine
- up-regulated by IL1-beta & IL6
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 1885 aa
MW = 207 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
N-glycosylation site {N117}
N-glycosylation site {N190}
N-glycosylation site {N267}
arginine-rich region {668-671}
MOTIF: arginine residue (SEVERAL)
N-glycosylation site {N757}
glutamine-rich region {1242-1245}
MOTIF: glutamine residue (SEVERAL)
N-glycosylation site {N1439}
Kazal-type serine protease inhibitor domain {1712-1744}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
FOR-BINDING-OF: serine protease
serine-rich region {1765-1768}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 608841
UniProt Q8IZJ3
PFAM correlations
Kegg hsa:2715
References
UniProt :accession Q8IZJ3