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B-WICH complex
Function:
- role in DNA damage recognition &/or DNA repair
Structure:
- subunits:
- SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A & DDX21
General
molecular complex
Properties
SUBUNITS: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 7-13
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S66}
Thr phosphorylation site {T113}
Thr phosphorylation site {T115}
Ser phosphorylation site {S116}
Ser phosphorylation site {S137}
helicase
NAME: helicase
SITE: 192-357
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 205-212
DEAD/H box
NAME: DEAD/H box
SITE: 308-311
Helicase C-terminal {487-638}
Ser phosphorylation site {S699}
Ser phosphorylation site {S755}
SANT 1 {840-892}
SANT 2 {943-1007}
bromodomain adjacent to zinc finger domain protein 1B
COMPARTMENT: cell nucleus
MOTIF: WAC {20-126}
lysine-rich region {306-578}
MOTIF: lysine residue (SEVERAL)
coiled coil {533-586}
DDT {604-668}
Ser phosphorylation site {S705}
Ser phosphorylation site {S708}
coiled coil {768-814}
coiled coil {850-893}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1184-1234
EFFECTOR-BOUND: Zn+2
coiled coil {1245-1283}
MOTIF: glutamate-rich region {1261-1273}
MOTIF: glutamate residue (SEVERAL)
bromodomain {1356-1426}
Ser phosphorylation site {S1468}
splicing factor 3B subunit 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Thr phosphorylation site {T142}
Thr phosphorylation site {T207}
Thr phosphorylation site {T211}
PPP1R8 interaction {223-491}
MOTIF: Thr phosphorylation site {T223}
Thr phosphorylation site {T227}
Thr phosphorylation site {T235}
Thr phosphorylation site {T244}
Thr phosphorylation site {T248}
Thr phosphorylation site {T267}
Thr phosphorylation site {T296}
Thr phosphorylation site {T299}
Thr phosphorylation site {T313}
Thr phosphorylation site {T316}
Thr phosphorylation site {T326}
Thr phosphorylation site {T328}
Ser phosphorylation site {S344}
Thr phosphorylation site {T350}
Thr phosphorylation site {T354}
HEAT repeat {529-568}
HEAT repeat {569-603}
HEAT repeat {604-641}
HEAT repeat {643-677}
HEAT repeat {680-718}
HEAT repeat {763-801}
HEAT repeat {843-881}
HEAT repeat {1010-1048}
HEAT repeat {1052-1090}
HEAT repeat {1122-1160}
HEAT repeat {1163-1201}
protein DEK
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
acidic region {30-49}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S32}
Ser phosphorylation site {S51}
SAP {149-183}
nuclear translocation signal {205-221}
Ser phosphorylation site {S227}
acidic region {228-236}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S230}
Ser phosphorylation site {S231}
Ser phosphorylation site {S232}
acidic region {241-254}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S243}
Ser phosphorylation site {S244}
Ser phosphorylation site {S251}
Ser phosphorylation site {S276}
acidic region {300-310}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S301}
Ser phosphorylation site {S303}
Ser phosphorylation site {S306}
Ser phosphorylation site {S307}
DNA-binding motif
SITE: 337-351
DNA-binding motif
SITE: 367-371
myosin-1c
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Myosin head-like {36-718}
MOTIF: Ser phosphorylation site {S38}
ATP-binding site
NAME: ATP-binding site
SITE: 140-147
Ser phosphorylation site {S408}
IQ motif {734-757}
IQ motif {758-786}
Ercc6
Myb-binding protein 1A
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: interaction with MYB {1-582}
MOTIF: Ser phosphorylation site {S11}
nuclear export signal {240-258}
nuclear export signal {263-281}
glutamate-rich region {720-784}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S775}
required for nuclear & nucleolar localization {1151-1328}
MOTIF: Ser phosphorylation site {S1159}
Ser phosphorylation site {S1163}
Ser phosphorylation site {S1241}
Ser phosphorylation site {S1267}
Ser phosphorylation site {S1290}
Ser phosphorylation site {S1308}
Ser phosphorylation site {S1314}
DEAD-box protein 21
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S13}
Ser phosphorylation site {S71}
Ser phosphorylation site {S89}
Ser phosphorylation site {S121}
Ser phosphorylation site {S164}
Ser phosphorylation site {S168}
Ser phosphorylation site {S171}
Ser phosphorylation site {S173}
Q motif {186-214}
helicase
NAME: helicase
SITE: 217-396
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 230-237
Thr phosphorylation site {T315}
DEVD box {339-342}
Helicase C-terminal {429-573}
3 X 5 AA repeats {724-748}
MOTIF: consensus repeat {724-728}
consensus repeat {734-738}
consensus repeat {744-748}
References
UniProt :accession Q03468
Components
bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein, Williams syndrome transcription factor, hWALP2, BAZ1B, WBSC10, WBSCR9, WSTF)
DEAD-box protein 21; ATP-dependent RNA helicase 2; nucleolar RNA helicase Gu; RH II/Gu (DDX21)
Myb-binding protein 1A (MYBBP1A, P160)
myosin-1c; myosin 1 beta; MM1-beta; MM1b (MYO1C)
protein DEK (DEK)
splicing factor 3B subunit 1 (spliceosome associated protein 155, SAP 155, SF3b155, pre-mRNA splicing factor SF3b 155 kD subunit, SF3B1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; sucrose nonfermenting protein 2 homolog; hSNF2H (SMARCA5, SNF2H, WCRF135)