B melanoma antigen 1; B melanoma antigen; antigen MZ2-BA; cancer/testis antigen 2.1; CT2.1 (BAGE, BAGE1)

Function: - unknown - antigen recognized on a melanoma by autologous cytolytic T-lymphocytes Structure: belongs to the BAGE family Alternative splicing: named isoforms=1 Expression: - not expressed in normal tissues, except in testis Pathology: - expressed with significant proportion in melanomas - more frequently expressed in metastatic melanomas than in primary melanomas - also expressed in bladder carcinomas, head & neck squamous cell carcinomas, lung cancer & breast carcinomas - not expressed in renal cell carcinoma, colorectal cancer prostatic carcinoma, leukemias or lymphomas. Genetics: - ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene - the BAGE family was expanded by juxtacentromeric movement &/or acrocentric exchanges - BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 & 21 & of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 & 21

General

melanoma associated antigen (MAGE) secreted protein testis-specific protein

Properties

SIZE: MW = 5 kD entity length = 43 aa COMPARTMENT: cellular compartment CELL: unspecified cell type WITHIN: testis MOTIF: signal sequence {1-17}

Database Correlations

OMIM 605167 UniProt Q13072 Pfam PF08180 Entrez Gene 574 Kegg hsa:574

References

UniProt :accession Q13072