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B. anthracis lethal toxin
One of two molecular complexes (edema toxin & lethal toxin) formed from exotoxins of the Bacillus anthracis virulence plasmid pXO1. The complex is formed from lethal factor & protective antigen. The complex facilitates entry of the toxin into host cells. Lethal toxin stimulates macrophages to release TNF-alpha & IL-1 beta which are partly responsible for the sudden death in anthrax.
Related
B. anthracis edema toxin
Bacillus anthracis
interleukin-1 beta; IL-1 beta; catabolin (IL1B, IL1F2)
tumor necrosis factor [TNF]-alpha; tumor necrosis factor ligand superfamily member 2; cachectin (TNF, TNFA, TNFSF2)
General
exotoxin
molecular complex
Properties
SUBUNITS: B anthracis edema factor
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
membrane region
binding site
FOR-BINDING-OF: G-alpha
Mg+2-binding site
EFFECTOR-BOUND: Mg+2
consensus
ATP-binding site
NAME: ATP-binding site
SITE: CYTOPLASMIC-LOOP-3
ATP-binding site
NAME: ATP-binding site
SITE: CYTOPLASMIC-TAIL
cytoplasmic domain {C-TERMINAL}
STATE: Inactive
B anthracis protective antigen
References
Dixon et al, NEJM 341:815, 1999
Components
B. anthracis edema factor (EF)
B. anthracis protective antigen