Search
Butyrate response factor 2 (protein TIS11D, EGF-response factor 2, ERF-2) (ZFP36L2 BRF2 ERF2 RNF162C TIS11D)
Function:
- probable regulatory protein involved in regulating the response to growth factors
- RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence.
- binds to the class 2 AU-rich element (ARE) in the 3'-UTR of target mRNAs & promotes their deadenylation & degradation
Structure: contains 2 C3H1-type zinc fingers
Compartment: nucleus (putative)
General
nuclear protein
RNA-binding protein
zinc finger protein
Properties
SIZE: MW = 51 kD
entity length = 494 aa
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {106-109}
glutamine-rich region {138-141}
MOTIF: glutamine residue (SEVERAL)
glycine-rich region {143-146}
RNA-binding {153-158}
Zinc finger
NAME: Zinc finger
SITE: 154-180
EFFECTOR-BOUND: Zn+2
binding site
SITE: 170-211
FOR-BINDING-OF: ribonucleic acid
Zinc finger
NAME: Zinc finger
SITE: 192-218
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 288-291
MOTIF: proline residue (SEVERAL)
alanine-rich region {323-332}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {384-390}
MOTIF: alanine residue (SEVERAL)
glutamine-rich region {395-401}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
UniProt P47974
References
UniProt :accession P47974