Search
C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; monocyte-derived receptor 15; MDR-15; CD185 (CXCR5, BLR1, MDR15)
Function:
- cytokine receptor
- binds to B-lymphocyte chemoattractant (BLC)
- role in B-cell migration into B-cell follicles of spleen & Peyer patches but not into those of mesenteric or peripheral lymph nodes
- may have a regulatory function in B-cell differentiation
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2; long & short
Expression:
- expression in mature B-cells
Pathology:
- expressed in Burkitt lymphoma cells
- may have a regulatory function in Burkitt lymphoma
Related
CXCR5 Ag in tissue
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
CXC chemokine receptor
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 372 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-55}
MOTIF: N-glycosylation site {N28}
transmembrane domain {56-76}
cytoplasmic loop {77-88}
transmembrane domain {89-109}
exoplasmic loop {110-124}
MOTIF: cysteine residue {C122}
MODIFICATION: cysteine residue {C202}
transmembrane domain {125-145}
cytoplasmic loop {146-167}
transmembrane domain {168-188}
exoplasmic loop {189-219}
MOTIF: N-glycosylation site {N196}
cysteine residue {C202}
MODIFICATION: cysteine residue {C122}
transmembrane domain {220-240}
cytoplasmic loop {241-259}
transmembrane domain {260-280}
exoplasmic loop {281-304}
transmembrane domain {305-325}
cytoplasmic domain {326-372}
References
- UniProt :accession P32302
- Wikipedia; CXC chemokine receptors entry
http://en.wikipedia.org/wiki/CXC_chemokine_receptors
Databases & Figures
OMIM 601613
UniProt P32302
Pfam PF00001
Entrez Gene 643
Kegg hsa:643
CXC ligand and receptor binding