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bullous diabeticorum

Etiology: - associated with diabetes mellitus - cause unknown - increased venous pressure & poor vascular supply may contribute Epidemiology: uncommon Pathology: - bullae originate at the dermal-epidermal junction - split occurs within the lamina lucida - immunofluorescence studies are negative - microangiopathy with hyalinosis of blood vessel wall seen in one patient Clinical manifestations: - blisters appear spontaneously without trauma on non erythematous skin - generally occurs on feet or lower leg, but case reported of lesions restricted to the hands [3] - bullae generally appear overnight - little pain or discomfort - bullae may be huge - bullae tense with rupture in ~ 1 week - lesions heal spontaneously, without scarring but may take weeks to heal - recurrence is common Management: - self-limited - cold wet compresses - hygiene

Related

bullous pemphigoid; parapemphigus necrobiosis lipoidica diabeticorum [NLD]

General

skin disease (dermatologic disorder, dermatopathy, dermatosis) diabetes mellitus complication

References

  1. Ananad KP and Kashyap AS Bullosis diabeticorum. Postgrad Med J 2004, 80:354 PMID: 15192170
  2. Basarab T et al, Bullosis diaberticorum. A case report and literature review. Clin Exp Dermatol 1995, 20:218 (review) PMID: 7671416
  3. Collet JT and Toonstra J Bullosis diabeticorum: a case with lesions restricted to the hands. Diabetes Care 1985 8:177 PMID: 3888564
  4. Bodman M et al, Bullosis diaberticorum. A report of twp cases with a review of the literature. J Am Podiatr Med Assoc 81:561 PMID: 1774644
  5. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012