BTB/POZ domain-containing protein KCTD1; K+ channel tetramerization domain-containing protein 1 (KCTD1, C18orf5)

Function: - may repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B & TFAP2C - sumoylated - can form homodimers - interacts with TFAP2A, TFAP2B & TFAP2C via the BTB domain Structure: - contains 1 BTB domain (POZ domain) Compartment: nucleus Expression: - expressed in mammary gland, kidney, brain & ovary Pathology: - defects in KCTD1 are associated with scalp-ear-nipple syndrome

General

BTB/POZ domain containing protein human longevity protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 257 aa MW = 29 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S9} Ser phosphorylation site {S12} BTB domain {30-100} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM correlations UniProt Q719H9 Pfam PF02214 Entrez Gene 284252 Kegg hsa:284252

References

UniProt :accession Q719H9