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bryostatin
Indication:
- investigational agent for treatment of Alzheimer's disease
Dosage:
- 20 ug IV
Mechanism of action:
- modulates protein kinase C-epsilon
- effects on neurons
- enhances synaptogenesis
- inhibits apoptosis
- reduces formation of beta-amyloid
- inhibits phosporylation of tau
Notes:
- isolated from the marine bryozoan Bugula neritina
General
neurologic agent
References
- Fiore K
Bryozoan Compound Tolerated in Alzheimer's Safety Study -
Bryostatin may preserve cognitive function, but more studies needed
MedPage Today. July 20, 2017.
https://www.medpagetoday.com/MeetingCoverage/AAIC/66785