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brother of CDO (protein BOC, BOC)
Function:
1) component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells
2) promotes differentiation of myogenic cells
3) part of a complex that contains BOC, CDON, NEO1, cadherins & CTNNB1
4) interacts with NTN3
5) interacts with CDH2 & CTNNB1
6) interacts with CDH15 only during the early stages of myoblast differentiation
Structure:
- N-glycosylated
- C-terminal cytoplasmic domain is not required for stimulation of myogenesis
- contains 3 fibronectin F3 modules
- contains 4 Ig-like C2-type domains (immunoglobulin-like)
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in skeletal muscle, heart, thymus, kidney & small intestine > brain, placenta, lung & colon mucosa
General
glycoprotein
membrane protein
Properties
SIZE: MW = 121 kD
entity length = 1114 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-30}
immunoglobulin superfamily domain {36-123}
MOTIF: cysteine residue {C57}
MODIFICATION: cysteine residue {C106}
N-glycosylation site {N65}
N-glycosylation site {N76}
N-glycosylation site {N98}
cysteine residue {C106}
MODIFICATION: cysteine residue {C57}
immunoglobulin superfamily domain {129-213}
MOTIF: cysteine residue {C150}
MODIFICATION: cysteine residue {C200}
N-glycosylation site {N189}
cysteine residue {C200}
MODIFICATION: cysteine residue {C150}
immunoglobulin superfamily domain {235-315}
MOTIF: cysteine residue {C252}
MODIFICATION: cysteine residue {C299}
N-glycosylation site {N275}
cysteine residue {C299}
MODIFICATION: cysteine residue {C252}
immunoglobulin superfamily domain {323-409}
MOTIF: cysteine residue {C344}
MODIFICATION: cysteine residue {C391}
cysteine residue {C391}
MODIFICATION: cysteine residue {C344}
fibronectin type III domain or F3 module {471-567}
MOTIF: N-glycosylation site {N517}
fibronectin type III domain or F3 module {605-699}
fibronectin type III domain or F3 module {712-809}
MOTIF: N-glycosylation site {N725}
N-glycosylation site {N759}
transmembrane domain {856-876}
Database Correlations
OMIM 608708
UniProt Q9BWV1
PFAM correlations
References
UniProt :accession Q9BWV1