bromodomain testis-specific protein (RING3-like protein, BRDT)

Function: 1) role in the transcriptional regulation of spermatogenesis 2) structural ATP-independent role in the reorganization of acetylated chromatin 3) interacts with histone H4 acetylated N-terminus via 2 bromodomains Structure: - contains 2 bromo domains Compartment: nucleus Alternative splicing: named isoforms=2 Expression: testis-specific, adult testis > embryo testis Pathology: - lack of expression may be correlated with male infertility

General

nuclear protein testis-specific protein

Properties

SIZE: MW = 108 kD entity length = 947 aa COMPARTMENT: cell nucleus MOTIF: bromodomain {44-116} bromodomain {287-359} coiled coil {417-470} coiled coil {591-621} serine-rich region {635-667} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 602144 UniProt Q58F21 Pfam PF00439

References

UniProt :accession Q58F21