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bromodomain-containing protein 3; RING3-like protein (BRD3, KIAA0043, RING3L)
Structure: contains 2 bromo domains
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression: ubiquitous
Pathology:
- chromosomal translocation t(9;15)(q34;q14) involving BRD3 with NUT is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
- t(9;15)(q34;q14 produces a BRD3-NUT fusion protein
General
Bromodomain-containing protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 726 aa
MW = 80 kD
COMPARTMENT: cell nucleus
MOTIF: bromodomain {51-123}
Ser phosphorylation site {S259}
Ser phosphorylation site {S263}
Ser phosphorylation site {S281}
bromodomain {326-398}
coiled coil {453-524}
lysine-rich region {487-555}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S563}
coiled coil {645-684}
MOTIF: breakpoint {647-648}
serine-rich region {676-725}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S680}
Ser phosphorylation site {S682}
Database Correlations
OMIM 601541
UniProt Q15059
Pfam PF00439
Entrez Gene 8019
Kegg hsa:8019
References
UniProt :accession Q15059