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broadly neutralizing antibody (bNAb, VRC01)
Notes:
- genes for broadly neutralizing antibodies may be inserted into an adenovirus vector for use in vectored immunoprophylaxis
- VRC01 (10 or 30 mg/kg) decreased acquisition of antibody-sensitive HIV1 by 75%, but did not prevent infection with nonsusceptible HIV1 [2]
- broadly neutralizing antibodies that neutralize all coronaviruses by targeting surface antigens common to all coronaviruses [3]
* VRC01 is a preparation of broadly neutralizing antibodies
General
immunoglobulin
References
- Balazs AB et al.
Vectored immunoprophylaxis protects humanized mice from
mucosal HIV transmission.
Nat Med 2014 Mar; 20:296.
PMID: 24509526
- Corey L and McElrath MJ.
One shot forward for HIV prevention.
Nat Med 2014 Mar 4; 20:241
PMID: 24603794
- Corey L et al.
Two randomized trials of neutralizing antibodies to prevent HIV-1 acquisition.
N Engl J Med 2021 Mar 18; 384:1003.
PMID: 33730454
https://www.nejm.org/doi/10.1056/NEJMoa2031738
- Tortorici MA, Czudnochowski N, Starr TN et al.
Broad sarbecovirus neutralization by a human monoclonal antibody.
Nature 2021 Sep 2; 597:103
PMID: 34280951
https://www.nature.com/articles/s41586-021-03817-4
- Pinto D, Sauer MM, Czudnochowski N et al.
Broad betacoronavirus neutralization by a stem helix-pecific human
antibody.
Science 2021. Sep 3; 373:1109.
PMID: 34344823
https://www.science.org/doi/10.1126/science.abj3321
- Martinez DR, Schafer A, Globeil S et al
A broadly cross-reactive antibody neutralizes and protects against
sarbecovirus challenge in mice.
Science Translational Medicine 2021. Nov 2.
https://www.science.org/doi/10.1126/scitranslmed.abj7125